Rapid Wireless Capacitor Charging Using a Multi-Tapped Inductively-Coupled Secondary Coil

This paper presents an inductive coupling system designed to wirelessly charge ultra-capacitors used as energy storage elements. Although ultra-capacitors offer the native ability to rapidly charge, it is shown that standard inductive coupling circuits only deliver maximal power for a specific load impedance which depends on coil geometries and separation distances. Since a charging ultra-capacitor can be modeled as an increasing instantaneous impedance, maximum power is thus delivered to the ultra-capacitor at only a single point in the charging interval, resulting in a longer than optimal charging time. Analysis of inductive coupling theory reveals that the optimal load impedance can be modified by adjusting the secondary coil inductance and resonant tuning capacitance. A three-tap secondary coil is proposed to dynamically modify the optimal load impedance throughout the capacitor charging interval. Measurement results show that the proposed architecture can expand its operational range by up to 2.5 × and charge a 2.5 F ultra-capacitor to 5 V upwards of 3.7 × faster than a conventional architecture.Semiconductor Research Corporation. Interconnect Focus Cente

An all-digital transmitter for pulsed ultra-wideband communication

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.Includes bibliographical references (p. 91-96).Applications like sensor networks, medical monitoring, and asset tracking have led to a demand for energy-efficient and low-cost wireless transceivers. These types of applications typically require low effective data rates, thus providing an opportunity to employ simple modulation schemes and aggressive duty-cycling. Due to their inherently duty-cycled nature, pulse-based Ultra-Wideband (UWB) systems are amenable to low-power operation by shutting off circuitry during idle mode between pulses. Furthermore, the use of non-coherent UWB signaling greatly simplifies both transmitter and receiver implementations, offering additional energy savings. This thesis presents an all-digital transmitter designed for a non-coherent pulsed UWB system. By exploiting relaxed center frequency tolerances in non-coherent wideband communication, the transmitter synthesizes UWB pulses from an energy efficient, single-ended digital ring oscillator. Dual capacitively-coupled digital power amplifiers (PAs) are used in tandem to generate bipolar phase modulated pulses for spectral scrambling purposes. By maintaining opposite common modes at the output of these PAs during idle mode (i.e. when no pulses are being transmitted), low frequency turn-on and turn-off transients typically associated with single-ended digital circuits driving single-ended antennas are attenuated by up to 12dB. Furthermore, four level digital pulse shaping is employed to attenuate RF side lobes by up to 20dB. The resulting dual power amplifiers achieve FCC compliant operation in the 3.5, 4.0, and 4.5GHz IEEE 802.15.4a bands without the use of any off-chip filters or large passive components. The transmitter is fabricated in a 90nm CMOS process and requires a core area of 0.07mm2. The entirely digital architecture consumes zero static bias current, resulting in an energy efficiency of 17.5pJ/pulse at data rates up to 15.6Mbps.by Patrick Philip Mercier.S.M

Communication and energy delivery architectures for personal medical devices

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 219-232).Advances in sensor technologies and integrated electronics are revolutionizing how humans access and receive healthcare. However, many envisioned wearable or implantable systems are not deployable in practice due to high energy consumption and anatomically-limited size constraints, necessitating large form-factors for external devices, or eventual surgical re-implantation procedures for in-vivo applications. Since communication and energy-management sub-systems often dominate the power budgets of personal biomedical devices, this thesis explores alternative usecases, system architectures, and circuit solutions to reduce their energy burden. For wearable applications, a system-on-chip is designed that both communicates and delivers power over an eTextiles network. The transmitter and receiver front-ends are at least an order of magnitude more efficient than conventional body-area networks. For implantable applications, two separate systems are proposed that avoid reimplantation requirements. The first system extracts energy from the endocochlear potential, an electrochemical gradient found naturally within the inner-ear of mammals, in order to power a wireless sensor. Since extractable energy levels are limited, novel sensing, communication, and energy management solutions are proposed that leverage duty-cycling to achieve enabling power consumptions that are at least an order of magnitude lower than previous work. Clinical measurements show the first system demonstrated to sustain itself with a mammalian-generated electrochemical potential operating as the only source of energy into the system. The second system leverages the essentially unlimited number of re-charge cycles offered by ultracapacitors. To ease patient usability, a rapid wireless capacitor charging architecture is proposed that employs a multi-tapped secondary inductive coil to provide charging times that are significantly faster than conventional approaches.by Patrick Philip Mercier.Ph.D

A 440pJ/bit 1Mb/s 2.4GHz multi-channel FBAR-based TX and an integrated pulse-shaping PA

A 2.4GHz TX in 65nm CMOS defines three channels using three high-Q FBARs and supports OOK, BPSK and MSK. The oscillators have -132dBc/Hz phase noise at 1MHz offset, and are multiplexed to an efficient resonant buffer. Optimized for low output power ≈-10dBm, a fully-integrated PA implements 7.5dB dynamic output power range using a dynamic impedance transformation network, and is used for amplitude pulse-shaping. Peak PA efficiency is 44.4% and peak TX efficiency is 33%. The entire TX consumes 440pJ/bit at 1Mb/s.Interconnect Focus Center (United States. Defense Advanced Research Projects Agency and Semiconductor Research Corporation

Multi-channel 180pJ/b 2.4GHz FBAR-based receiver

A three-channel 2.4GHz OOK receiver is designed in 65nm CMOS and leverages MEMS to enable multiple sub-channels of operation within a band at a very low energy per received bit. The receive chain features an LNA/mixer architecture that efficiently multiplexes signal pathways without degrading the quality factor of the resonators. The single-balanced mixer and ultra-low power ring oscillator convert the signal to IF, where it is efficiently amplified to enable envelope detection. The receiver consumes a total of 180pJ/b from a 0.7V supply while achieving a BER=10-3 sensitivity of -67dBm at a 1Mb/s data rate.Semiconductor Research Corporation. Interconnect Focus CenterNatural Sciences and Engineering Research Council of Canada (Fellowship

A Sub-nW 2.4 GHz Transmitter for Low Data-Rate Sensing Applications

This paper presents the design of a narrowband transmitter and antenna system that achieves an average power consumption of 78 pW when operating at a duty-cycled data rate of 1 bps. Fabricated in a 0.18 μm CMOS process, the transmitter employs a direct-RF power oscillator topology where a loop antenna acts as a both a radiative and resonant element. The low-complexity single-stage architecture, in combination with aggressive power gating techniques and sizing optimizations, limited the standby power of the transmitter to only 39.7 pW at 0.8 V. Supporting both OOK and FSK modulations at 2.4 GHz, the transmitter consumed as low as 38 pJ/bit at an active-mode data rate of 5 Mbps. The loop antenna and integrated diodes were also used as part of a wireless power transfer receiver in order to kick-start the system power supply prior to energy harvesting operation.Semiconductor Research Corporation. Interconnect Focus CenterSemiconductor Research Corporation. C2S2 Focus CenterNational Institutes of Health (U.S.) (Grant K08 DC010419)National Institutes of Health (U.S.) (Grant T32 DC00038)Bertarelli Foundatio

A 1.1 nW Energy-Harvesting System with 544 pW Quiescent Power for Next-Generation Implants

This paper presents a nW power management unit (PMU) for an autonomous wireless sensor that sustains itself by harvesting energy from the endocochlear potential (EP), the 70-100 mV electrochemical bio-potential inside the mammalian ear. Due to the anatomical constraints inside the inner ear, the total extractable power from the EP is limited close to 1.1-6.25 nW. A nW boost converter is used to increase the input voltage (30-55 mV) to a higher voltage (0.8-1.1 V) usable by CMOS circuits in the sensor. A pW charge pump circuit is used to minimize the leakage in the boost converter. Furthermore, ultralow-power control circuits consisting of digital implementations of input impedance adjustment circuits and zero current switching circuits along with Timer and Reference circuits keep the quiescent power of the PMU down to 544 pW. The designed boost converter achieves a peak power conversion efficiency of 56%. The PMU can sustain itself, and a duty-cyled ultralow-power load while extracting power from the EP of a live guinea pig. The PMU circuits have been implemented on a 0.18- μm CMOS process.Semiconductor Research Corporation. Focus Center for Circuit and System Solutions (C2S2)Interconnect Focus Center (United States. Defense Advanced Research Projects Agency and Semiconductor Research Corporation)National Institutes of Health (U.S.) (Grant K08 DC010419)National Institutes of Health (U.S.) (Grant T32 DC00038)Bertarelli Foundatio

ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.Peer reviewe

Crowdsourcing hypothesis tests: Making transparent how design choices shape research results

To what extent are research results influenced by subjective decisions that scientists make as they design studies? Fifteen research teams independently designed studies to answer fiveoriginal research questions related to moral judgments, negotiations, and implicit cognition. Participants from two separate large samples (total N > 15,000) were then randomly assigned to complete one version of each study. Effect sizes varied dramatically across different sets of materials designed to test the same hypothesis: materials from different teams renderedstatistically significant effects in opposite directions for four out of five hypotheses, with the narrowest range in estimates being d = -0.37 to +0.26. Meta-analysis and a Bayesian perspective on the results revealed overall support for two hypotheses, and a lack of support for three hypotheses. Overall, practically none of the variability in effect sizes was attributable to the skill of the research team in designing materials, while considerable variability was attributable to the hypothesis being tested. In a forecasting survey, predictions of other scientists were significantly correlated with study results, both across and within hypotheses. Crowdsourced testing of research hypotheses helps reveal the true consistency of empirical support for a scientific claim.</div

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707